منابع مشابه
Implicit dose-response curves.
We develop tools from computational algebraic geometry for the study of steady state features of autonomous polynomial dynamical systems via elimination of variables. In particular, we obtain nontrivial bounds for the steady state concentration of a given species in biochemical reaction networks with mass-action kinetics. This species is understood as the output of the network and we thus bound...
متن کاملParallel dose-response curves in combination experiments.
A possible experimental design for combination experiments is to compare the dose-response curve of a single agent with the corresponding curve of the same agent using either a fixed amount of a second one or a fixed dose ratio. No interaction is then often defined by a parallel shift of these curves. We have performed a systematic study for various types of dose-response relations both for the...
متن کاملThe steep dose-response curves of anesthesia.
To the Editor:—The critique by Eger et al. on the article by Eckenhoff and Johansson concerns combining the dose–response curves of several ion channels to make them steeper. The slopes of the in vivo studies are steep, whereas those of the in vitro studies are gradual. Both groups anticipate that when several binding sites among ion channels are combined, the dose–response curves may become st...
متن کاملMathematical modeling improves EC50 estimations from classical dose-response curves.
UNLABELLED The β-adrenergic response is impaired in failing hearts. When studying β-adrenergic function in vitro, the half-maximal effective concentration (EC50 ) is an important measure of ligand response. We previously measured the in vitro contraction force response of chicken heart tissue to increasing concentrations of adrenaline, and observed a decreasing response at high concentrations. ...
متن کاملMaximum likelihood estimation for cytogenetic dose-response curves.
In vitro dose-response curves are used to describe the relation between chromosome aberrations and radiation dose for human lymphocytes. The lymphocytes are exposed to low-LET radiation, and the resulting dicentric chromosome aberrations follow the Poisson distribution. The expected yield depends on both the magnitude and the temporal distribution of the dose. A general dose-response model that...
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ژورنال
عنوان ژورنال: Journal of Mathematical Biology
سال: 2014
ISSN: 0303-6812,1432-1416
DOI: 10.1007/s00285-014-0809-4